Potential risk factors included the total number of instances of vaginal intercourse (continuous variable), the number of new partners (0, 1, or >1), the frequency of condom use by partners (<5 percent, 5 to 49 percent, 50 to 99 percent, or 100 percent), the partner's circumcision status (circumcised, uncircumcised, or unknown), and the partner's number of previous partners (0, ?1, or unknown). The frequency of condom use was calculated by dividing the number of condoms used for vaginal intercourse by the number of instances of vaginal intercourse during the eight-month study period. If multiple new partners were reported during an eight-month period, the circumcision status and previous number of partners were summarized ( Table 1 ). The percentage of days that lacked diary entries was calculated to assess potential confounding created by missing data. The effect of the frequency of condom use was evaluated by multivariate analysis with the inclusion of other variables that were found to be significant (P<0.10) in univariate analyses. Similar analyses were performed to evaluate risk factors for high-risk types of HPV (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 67, 68, 73, and 82), 20,21 low-risk types (6, 11, 40, 42, 54, 55, 57, 61, 62, 64, 69, 70, 71, 72, 81, 83, 84, and CP6108), 20,21 and types 6, 11, 16, and 18 (which are included in quadrivalent vaccine trials 22 ). To evaluate whether the effect of condom use on the risk of HPV infection differed according to the location in the genital tract, similar analyses were performed to examine risk factors for incident cervical and vulvovaginal infections.
In the subanalyses, victims whoever people utilized condoms 100 % of time have been put into several groups on the basis of their answers so you can the question “Performed your partner’s penis previously touching the hole of pussy instead a condom?” When the victims always responded “no” each act from vaginal intercourse in the 7-week period, they were coded just like the which have had “zero genital get in touch with versus an excellent condom.” Analyses was performed as demonstrated a lot more than, with four kinds of the latest frequency out of condom play with (100 % with no vaginal contact instead a good condom, 100 percent with or an as yet not known frequency out-of genital get in touch with without an effective condom, and you may around three communities less than completely, because the revealed a lot more than).
Furthermore, Cox proportional-dangers models were utilized to determine exposure facts on the identification off event cervical squamous intraepithelial sores in the seven weeks ahead of certain Pap take to (on the basis of a past observation that most sores occur soon after experience illness 23 ). A great 51-go out slowdown before every go to are included due to the fact 51 months try the latest shortest noticed interval within big date a lady very first had intercourse therefore the day out of detection out-of a case lesion inside this research. Research to own eg subjects was basically censored pursuing the very first detection off an instance lesion.
Performance
New mean (±SD) period of this new 82 sufferers in the subscription are 19.3±0.eight decades. The sufferers completed 709 visits. The brand new imply realize-upwards time is actually 33.9±eleven.8 weeks, the new suggest quantity of check outs for every single lady are 8.6±dos.9, as well as the median time between check outs are cuatro.step one days. Log investigation were ninety.7 percent done, and you may condom analysis have been filed into the 99.step Spanish Sites dating online 3 per cent out of months you to definitely intercourse is reported.
Dining table dos
The brand new a dozen-day cumulative chance out of a first HPV disease just after earliest sex are 37.dos % (95 % depend on period, twenty seven.2 so you’re able to forty two.cuatro per cent). All in all, 126 experience sort of-particular attacks was understood when you look at the forty female after they first had intercourse ( Table 2 ). Incident bacterial infections was indeed known during the about three girls ahead of they stated with gender for the first time, along with that positive to have HPV sort of 51, that for HPV type of six, and another for HPV designs forty, 61, and you may 66. Brand new twenty four-week cumulative frequency away from cervical squamous intraepithelial sores try fifteen.0 % (95 per cent confidence period, 8.step three in order to 26.dos per cent).